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The product code(s) for this leaflet is: PL 06934/0226.
Aprepitant 125 mg hard capsules / Aprepitant 80 mg hard capsules
Aprepitant 125 mg hard capsules
Aprepitant 80 mg hard capsules
aprepitant
1. What Aprepitant capsules are and what they are used for
2. What you need to know before you take or give Aprepitant capsules
3. How to take Aprepitant capsules
4. Possible side effects
5. How to store Aprepitant capsules
6. Contents of the pack and other information
Aprepitant capsules contain the active substance aprepitant and belong to a group of medicines called ‘neurokinin 1 (NK1) receptor antagonists‘. The brain has a specific area that controls nausea and vomiting. Aprepitant capsules work by blocking signals to that area, thereby reducing nausea and vomiting. Aprepitant capsules are used in adults and adolescents from the age of 12 years in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (cancer treatment) that are strong and moderate triggers of nausea and vomiting (such as cisplatin, cyclophosphamide, doxorubicin or epirubicin).
Talk to the doctor, pharmacist or nurse before you take or give this medicine to the child.
Before treatment with Aprepitant capsules, tell the doctor if you or the child have liver disease because the liver is important in breaking down the medicine in the body. The doctor may therefore have to monitor the condition of your or the child’s liver.
Do not give Aprepitant 80 mg and 125 mg capsules to children under 12 years of age, because the 80 mg and 125 mg capsules have not been studied in this population.
Aprepitant capsules can affect other medicines both during and after treatment with Aprepitant capsules. There are some medicines that should not be taken with Aprepitant capsules (such as pimozide, terfenadine, astemizole, and cisapride) or that require a dose adjustment (see also ‘Do not take Aprepitant capsules’).
The effects of Aprepitant capsules or other medicines might be influenced if you or the child take Aprepitant capsules together with other medicines including those listed below. Please talk to the doctor or pharmacist if you or the child is taking any of the following medicines:
Tell the doctor or pharmacist if you or the child are taking, have recently taken, or might take any other medicines.
This medicine should not be used during pregnancy unless clearly necessary. If you or the child are pregnant or breast-feeding, may be pregnant or are planning to have a baby, ask the doctor for advice before taking this medicine.
For information regarding birth control, see ‘Other medicines and Aprepitant capsules‘.
It is not known whether Aprepitant capsules are excreted in human milk; therefore, breast-feeding is not recommended during treatment with this medicine. It is important to tell the doctor if you or the child are breast-feeding or are planning to breast-feed before taking this medicine.
It should be taken into account that some people feel dizzy and sleepy after taking Aprepitant capsules. If you or the child feels dizzy or sleepy, avoid driving, riding a bicycle or using machines or tools after taking this medicine (see ‘Possible side effects’).
Aprepitant capsules contain sucrose. If you or the child have been told by your doctor that you or the child have an intolerance to some sugars, contact the doctor before taking this medicine.
Aprepitant capsules contain less than 1 mmol sodium (23 mg) per capsule, that is to say essentially ‘sodium-free’.
Always take this medicine or give this medicine to the child exactly as the doctor, pharmacist or nurse has told you. You should check with the doctor, pharmacist or nurse if you are not sure. Always take Aprepitant capsules together with other medicines, to prevent nausea and vomiting. After treatment with Aprepitant capsules, the doctor may ask you or the child to continue taking other medicines including a corticosteroid (such as dexamethasone) and a ‘5HT3 antagonist’ (such as ondansetron) for preventing nausea and vomiting. Check with the doctor, pharmacist or nurse if you are not sure.
The recommended oral dose of Aprepitant capsules is
Day 1:
and
Day 2 and 3:
Aprepitant capsules can be taken with or without food.
Swallow the capsule whole with some liquid
Do not take more capsules than the doctor recommends. If you or the child has taken too many capsules, contact your doctor immediately.
If you or the child has missed a dose, contact the doctor for advice.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Other side effects that have been reported are listed below.
Common side effects (may affect up to 1 in 10 people) are:
Uncommon side effects (may affect up to 1 in 100 people) are:
Rare side effects (may affect up to 1 in 1,000 people) are:
If you or the child gets any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of that month.
This medicine does not require any special storage conditions.
Do not remove the capsule from its blister until you are ready to take it.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
The 125 mg capsule is size 1 capsule and has an opaque pink cap and an opaque white body, printed with “125 mg” in black ink.
The 80 mg capsule is size 2 capsule and has an opaque white cap and an opaque white body printed with “80 mg” in black ink.
Aprepitant 125 mg capsules are supplied in the following pack sizes:
Aprepitant 80 mg capsules are supplied in the following pack size:
Aprepitant 125 mg and 80 mg capsules are supplied in the following pack size:
Not all pack sizes may be marketed.
Marketing Authorisation Holder
Manufacturer
For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:
This leaflet was last revised in 02/2022.
D05634