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The text only version may be available in large print, Braille or audio CD. For further information call emc accessibility on 0800 198 5000. The product code(s) for this leaflet is: PL39699/0045.
Tioguanine 40 mg Tablets
Tioguanine 40 mg tablets
tioguanine
1. What Tioguanine is and what it is used for
2. What you need to know before you take Tioguanine
3. How to take Tioguanine
4. Possible side effects
5. How to store Tioguanine
6. Contents of the pack and other information
Tioguanine tablets contain a medicine called tioguanine. This belongs to a group of medicines called cytotoxics (also called chemotherapy). Tioguanine is used for certain blood problems and cancers of the blood. It works by reducing the number of new blood cells your body makes.
Tioguanine is used for acute (fast-growing) leukaemias, especially:
Ask your doctor if you would like more explanation about these diseases.
if you are allergic (hypersensitive) to tioguanine or any of the other ingredients of this medicine (listed in section 6).
Talk to your doctor, pharmacist or nurse before taking Tioguanine:
If you are not sure if any of the above apply to you, talk to your doctor, nurse or pharmacist before taking Tioguanine.
If you have an inherited mutation in the NUDT15-gene (a gene which is involved in the break-down of Tioguanine in the body), you have a higher risk of infections and hair loss and your doctor may in this case give you a lower dose. Your doctor may also perform genetic testing (i.e. looking at your TPMT and/or NUDT15 genes) before or during your treatment to determine if your response to this medication may be affected by your genetics. Your doctor may change your dose of Tioguanine after these tests.
While taking Tioguanine you may become sensitive to the sunlight which can cause skin discolouration or a rash. Take care to avoid too much sun, cover up and use sunscreen.
Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.
In particular tell your doctor or pharmacist if you are taking any of the following:
If you are going to have a vaccination speak to your doctor or nurse before you have it. This is because some vaccines (like polio, measles, mumps and rubella) may give you an infection if you have them whilst you are taking Tioguanine.
If you are pregnant or are planning to have a baby, ask your doctor for advice before you take Tioguanine. This applies to both men and women. Tioguanine may harm your sperm or eggs. Reliable contraceptive precautions must be taken to avoid pregnancy whilst you or your partner are taking these tablets. If you are breast-feeding, ask your doctor or midwife for advice before taking Tioguanine.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Tioguanine should only be given to you by a specialist doctor who is experienced in treating blood problems.
Always take this medicine exactly as your doctor has told you. It is important to take your medicine at the right times. The label on your pack will tell you how many tablets to take and how often to take them. Check with your doctor, pharmacist or nurse if you are not sure.
The dose of Tioguanine you are given will be worked out by your doctor based on:
If you take more Tioguanine than you should, tell your doctor immediately or go to a hospital straight away. Take the medicine pack with you.
Tell your doctor. Do not take a double dose to make up for a forgotten dose.
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Talk to your doctor if you have any of the following side effects which may also happen with this medicine:
Very common (may affect more than 1 in 10 people)
Common (may affect up to 1 in 10 people)
Rare (may affect up to 1 in 1,000 people)
Not known: frequency cannot be estimated from the available data
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
The active substance is Tioguanine. Each Tioguanine tablet contains 40 mg of tioguanine.
The other ingredients are lactose monohydrate, starch (potato), acacia, stearic acid, magnesium stearate and purified water.
Tioguanine tablets are white to off-white tablets, round, biconvex scored and imprinting ‘T40’ on upper side, without score and debossing on lower side. Your Tioguanine tablets are in bottles of 25 tablets.
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For any Medical Information enquiries about this product, please contact: 24 Hour Helpline +44 1748 828 391 (free phone UK only 0800 0087 392)
This leaflet was last revised in September 2017
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Product name Tioguanine 40mg tablets
Reference number PL 39699/ 0045
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